FBXO9
Description
The FBXO9 (F-box protein 9) is a protein-coding gene located on chromosome 6.
FBXO9 is a gene that encodes a protein belonging to the F-box protein family. These proteins are characterized by an F-box motif and are part of the SCF (SKP1-cullin-F-box) ubiquitin protein ligase complex involved in phosphorylation-dependent ubiquitination. FBXO9 falls under the Fbxs class of F-box proteins. Alternative splicing of the FBXO9 gene generates multiple transcript variants.
FBXO9 is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. It targets specific proteins for ubiquitination, leading to their degradation by the proteasome. FBXO9 plays a role in several cellular processes, including cell cycle regulation, cell proliferation, and maintenance of chromosome stability. It specifically ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2, leading to their degradation and inactivation of mTORC1. This inactivation restrains cell growth and protein translation. In contrast, FBXO9 does not ubiquitinate TTI1 and TELO2 when they are part of the mTORC2 complex, allowing for mTORC2 activation. FBXO9 also contributes to epithelial cell survival by regulating the turnover of the chromatin modulator PRMT4 through ubiquitination and degradation. Additionally, FBXO9 regulates PPARgamma stability by facilitating its ubiquitination, playing a role in adipocyte differentiation.
FBXO9 is also known as FBX9, NY-REN-57, VCIA1, dJ341E18.2.
Associated Diseases
- cancer
- substance abuse
- cholesterol-ester transfer protein deficiency
- thyroid hormone metabolism, abnormal, 2
- hypothyroidism, congenital, nongoitrous
- hypertriglyceridemia 2
- Parkinson disease
- Miyoshi myopathy
