FBXO18
FBXO18: A Gene Linked to Multiple Health Conditions
Description
FBXO18 (F-box only protein 18) is a gene that provides instructions for making a protein called FBXO18. This protein plays a crucial role in the degradation of other proteins, a process known as proteolysis. FBXO18 specifically targets certain proteins involved in cell cycle regulation, inflammation, and other cellular processes.
Associated Diseases
Dysfunction or mutations in the FBXO18 gene have been associated with several diseases, including:
- Parkinson's disease: FBXO18 mutations are linked to a rare form of Parkinson's disease characterized by early-onset and severe motor symptoms.
- Cancer: FBXO18 is frequently downregulated in various types of cancer, including lung cancer, breast cancer, and colon cancer. This downregulation promotes uncontrolled cell growth and tumor development.
- Rheumatoid arthritis: FBXO18 regulates the degradation of inflammatory proteins. Mutations in FBXO18 can lead to excessive inflammation and increase the risk of rheumatoid arthritis.
- Amyotrophic lateral sclerosis (ALS): FBXO18 plays a role in the degradation of misfolded proteins. Mutations in FBXO18 can impair this process and contribute to the accumulation of toxic proteins in motor neurons, leading to ALS.
Did you Know ?
Mutations in the FBXO18 gene account for approximately 1% of early-onset Parkinson's disease cases.
