FBXO15
Description
The FBXO15 (F-box protein 15) is a protein-coding gene located on chromosome 18.
FBXO15 is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which is responsible for targeting proteins for degradation by the proteasome.
FBXO15 is also known as FBX15.
Associated Diseases
- neutrophil immunodeficiency syndrome
- hereditary neutrophilia
- X-linked severe congenital neutropenia
- transient myeloproliferative syndrome
- linear and whorled nevoid hypermelanosis
- myeloperoxidase deficiency
- neutropenia, severe congenital, 1, autosomal dominant
- idiopathic hypereosinophilic syndrome
- neutropenia, severe congenital, 2, autosomal dominant
- ichthyosis prematurity syndrome
- reticular dysgenesis
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency
