FBXL21
FBXL21: A Key Player in Protein Degradation and Disease
Description
FBXL21 is a protein encoded by the FBXL21 gene in humans. It belongs to the F-box protein family, which are critical components of the ubiquitin ligase complex, responsible for directing proteins to degradation.
FBXL21 is highly conserved across species, indicating its essential role in cellular processes. It interacts with various substrates and targets them for ubiquitination, the process by which proteins are marked for degradation.
Associated Diseases
Dysregulation of FBXL21 has been linked to a number of human diseases, including:
- Parkinson's Disease: FBXL21 has been identified as a genetic risk factor for Parkinson's disease, a neurodegenerative disorder characterized by tremors, stiffness, and impaired balance.
- Alzheimer's Disease: Studies suggest that FBXL21 may play a role in Alzheimer's disease, as it is involved in controlling the levels of amyloid beta, a protein that forms plaques in the brains of Alzheimer's patients.
- Cancer: FBXL21 has been found to be downregulated in certain types of cancer, such as breast and lung cancer. Its loss may contribute to tumor growth and progression.
Did you Know ?
Approximately 2% of Parkinson's disease cases are estimated to be associated with mutations in the FBXL21 gene. This highlights the significant role of FBXL21 in the development of this neurodegenerative disorder.
