FBXL19
Description
The FBXL19 (F-box and leucine rich repeat protein 19) is a protein-coding gene located on chromosome 16.
FBXL19 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It plays a role in various cellular processes, including cell migration, proliferation, and cytoskeletal reorganization. FBXL19 mediates the ubiquitination and degradation of RHOA in an ERK2-dependent manner, and also induces RAC1 and RAC3 degradation through the proteasome system, thereby regulating TGFB1-induced E-cadherin down-regulation and cell migration. FBXL19 also mediates the ubiquitination and degradation of IL-33-induced receptor IL1RL1, preventing IL-33-mediated apoptosis. Within the nucleus, FBXL19 binds to DNA containing unmethylated CpG dinucleotides. It recruits CDK-mediator to chromatin, targets CDK8 to promoters of silent developmental genes, and induces these genes during cell differentiation. Additionally, FBXL19 is crucial for the recruitment of RNF20 to histone H2B, leading to H2B mono-ubiquitination.
FBXL19 is also known as CXXC11, Fbl19, JHDM1C.
