FASTKD1
Description
The FASTKD1 (FAST kinase domains 1) is a protein-coding gene located on chromosome 2.
FAST kinase domain-containing protein 1 (FASTKD1) is a protein encoded by the FASTKD1 gene on chromosome 2 in humans. It belongs to the FASTKD family, which plays a role in regulating mitochondrial energy balance under stress. FASTKD1 contains an N-terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and an RNA-binding domain (RAP). Its mitochondrial targeting domain directs it to the mitochondria, where it likely modulates energy balance, particularly under stress conditions. Although ubiquitously expressed, FASTKD1 is more abundant in skeletal and heart muscle, tissues with high mitochondrial density. FASTKD1 has been identified as an RNA-binding protein. Additionally, it plays a role in apoptosis. Importantly, FASTKD1's involvement in the downregulation of mitochondrial MT-ND3 mRNA levels leads to a decrease in the abundance and activity of respiratory complex I.
FASTKD1 is also known as -.
