FARP2
Description
The FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2) is a protein-coding gene located on chromosome 2.
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene. FARP2 has been shown to interact with PDZK1.
FARP2 acts as a guanine nucleotide exchange factor, activating RAC1. Although its activity is relatively low, it plays a crucial role in responding to class 3 semaphorins and remodeling the actin cytoskeleton. FARP2 is also involved in TNFSF11-mediated osteoclast differentiation, particularly in podosome rearrangement and actin cytoskeleton reorganization. Additionally, it regulates the activation of ITGB3, integrin signaling, and cell adhesion.
FARP2 is also known as FIR, FRG, PLEKHC3.
