FAM98B
Headline: FAM98B: An Emerging Player in Health and Disease
Description:
FAM98B (family with sequence similarity 98, member B) is a multifaceted protein with diverse cellular functions. It belongs to a family of transmembrane proteins known as the FAM98 family, which play crucial roles in cell adhesion, migration, and signaling. FAM98B is primarily localized to the plasma membrane, where it interacts with a range of proteins involved in various cellular processes.
Associated Diseases:
Dysregulation of FAM98B has been implicated in several human diseases, including:
- Cancer: FAM98B overexpression has been linked to increased tumor growth and metastasis in several types of cancer, including breast cancer, lung cancer, and colorectal cancer. Studies suggest that FAM98B promotes tumor progression by enhancing cell migration and invasion.
- Neurodegenerative diseases: Reduced FAM98B expression has been associated with neurodegenerative disorders such as Alzheimer‘s disease and Parkinson‘s disease. FAM98B is believed to play a protective role in neurons by regulating synaptic function and protecting against oxidative stress.
- Immune disorders: FAM98B has been implicated in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. It is thought to contribute to the inflammatory response and regulate the function of immune cells.
Did you Know ?
According to a recent study, decreased FAM98B expression was observed in approximately 60% of Alzheimer‘s disease patients. This finding highlights the potential role of FAM98B as a biomarker for early diagnosis and therapeutic intervention in neurodegenerative diseases.
