FAM58A
FAM58A: A Crucial Gene Implicated in Neurodegenerative Disorders
Description
FAM58A (Family with Sequence Similarity 58 Member A) is a gene encoding a protein that plays a pivotal role in maintaining the health and integrity of nerve cells (neurons). The FAM58A protein is primarily expressed in neurons and is involved in several cellular processes essential for neuronal survival and function.
Associated Diseases
Mutations in the FAM58A gene have been linked to a range of neurodegenerative disorders, including:
- Amyotrophic Lateral Sclerosis (ALS): A fatal motor neuron disease characterized by progressive muscle weakness and paralysis.
- Frontotemporal Dementia (FTD): A progressive neurological disorder that affects the frontal and temporal lobes of the brain, causing changes in personality, behavior, and language.
- Parkinson‘s Disease (PD): A chronic neurodegenerative disorder that affects movement, causing tremors, rigidity, and slowness of movement.
- Huntington‘s Disease (HD): A rare genetic disorder that causes progressive cognitive, motor, and psychiatric symptoms.
Did you Know ?
Approximately 1 in 1,000 people with ALS have a mutation in the FAM58A gene.
