FAF2
Description
The FAF2 (Fas associated factor family member 2) is a protein-coding gene located on chromosome 5.
FAF2 plays a critical role in the process of endoplasmic reticulum-associated degradation (ERAD), where it facilitates the ubiquitin-dependent breakdown of misfolded proteins within the endoplasmic reticulum. Additionally, FAF2 indirectly controls the insulin-like growth factor receptor signaling pathway by regulating the expression of the IGF1R receptor. Furthermore, FAF2 inhibits lipid droplet degradation by binding to the phospholipase PNPL2, preventing its activity and promoting its separation from its activator, ABHD5, ultimately slowing down the breakdown of triacylglycerol. FAF2 also participates in stress granule disassembly. In response to heat shock, it binds to ubiquitinated G3BP1, promoting its interaction with VCP, which leads to the removal of G3BP1 from stress granules and the subsequent disassembly of these structures.
FAF2 is also known as ETEA, UBXD8, UBXN3B.
