FABP5

Description

The FABP5 (fatty acid binding protein 5) is a protein-coding gene located on chromosome 8.

FABP5, or Fatty acid-binding protein, epidermal, is a protein encoded by the FABP5 gene in humans. This protein is found in epidermal cells and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. Phytocannabinoids, such as THC and CBD, inhibit the uptake of the endocannabinoid anandamide (AEA) by targeting FABP5, and competition for FABPs may explain the increased circulating levels of endocannabinoids reported after consuming cannabinoids. Cannabinoids inhibit keratinocyte proliferation, suggesting a potential role for cannabinoids in treating psoriasis. FABP5 has been shown to interact with S100A7.

FABP5 acts as an intracellular carrier for long-chain fatty acids and related active lipids, including endocannabinoids, regulating their metabolism and activity. Beyond cytosolic transport, it selectively delivers specific fatty acids from the cytosol to the nucleus, activating nuclear receptors. This includes delivery of retinoic acid to the peroxisome proliferator-activated receptor delta, promoting proliferation and survival. Additionally, FABP5 may function as a synaptic carrier of endocannabinoids at central synapses, controlling retrograde endocannabinoid signaling. It modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. FABP5 may also play a role in keratinocyte differentiation.

FABP5 is also known as E-FABP, EFABP, KFABP, PA-FABP, PAFABP.

Associated Diseases

WES Whole Exome Sequencing