FAAH2

Description

The FAAH2 (fatty acid amide hydrolase 2) is a protein-coding gene located on chromosome X.

FAAH2 is an enzyme belonging to the serine hydrolase family. It breaks down endocannabinoids. Defects in FAAH2 have been linked to neurological and psychiatric disorders.

FAAH2 breaks down fatty amides, including sleep-inducing oleamide and the endocannabinoid anandamide, into their corresponding fatty acids. This regulates the signaling functions of these molecules. FAAH2 prefers monounsaturated anandamide over polyunsaturated substrates. This information comes from publications referenced in PubMed IDs 17015445 and 19926788.

FAAH2 is also known as AMDD.

Associated Diseases

• type 2 diabetes mellitus
• nonpapillary renal cell carcinoma
• psychiatric disorder
• COVID-19
• Turner syndrome
• X-linked intellectual disability