F11R
Description
The F11R (F11 receptor) is a protein-coding gene located on chromosome 1.
F11R, also known as JAM-A, is a protein encoded by the F11R gene in humans. It is also designated as CD321. F11R is a key regulator of tight junction assembly in epithelial cells, contributing to the formation of tight seals between cells and preventing the free passage of solutes and water. It acts as a receptor for reovirus, a ligand for integrin LFA1 involved in leukocyte transmigration, and a platelet receptor. Two isoforms of F11R are encoded by the gene.
F11R, also known as JAM-A, plays a crucial role in the formation of tight junctions in epithelial cells. It appears early in the development of cell junctions and recruits PARD3, a protein involved in tight junction assembly. The association of PARD6-PARD3 complex can inhibit the interaction between PARD3 and JAM1, potentially preventing the formation of tight junctions. F11R also regulates monocyte transmigration, contributing to the integrity of the epithelial barrier. It acts as a ligand for integrin alpha-L/beta-2, facilitating the transmigration of memory T-cells and neutrophils. Additionally, F11R participates in platelet activation.
F11R is also known as CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1.
