ESRRG
Description
The ESRRG (estrogen related receptor gamma) is a protein-coding gene located on chromosome 1.
ESRRG (Estrogen Related Receptor Gamma) is a nuclear receptor encoded by the ESRRG gene. It functions as a constitutive activator of transcription, meaning it doesn't require a specific ligand to activate. While no physiological activating ligand is known for ESRRG, certain compounds like 4-hydroxytamoxifen and diethylstilbestrol can deactivate it by acting as inverse agonists. Bisphenol A (BPA) has been identified as a potential target for ESRRG. BPA binds strongly to ESRRG, preserving its basal constitutive activity and protecting it from deactivation by 4-hydroxytamoxifen. The varying expression levels of ESRRG in different parts of the body could contribute to the diverse effects of BPA. For example, high concentrations of ESRRG are found in the placenta, explaining reports of high BPA accumulation in this tissue.
ESRRG is an orphan receptor that acts as a transcriptional activator in the absence of bound ligands. It binds specifically to estrogen response elements (EREs) and activates reporter genes controlled by EREs. ESRRG induces the expression of PERM1 in skeletal muscle.
ESRRG is also known as ERR-gamma, ERR3, ERRg, ERRgamma, NR3B3.
