ERRFI1
Description
The ERRFI1 (ERBB receptor feedback inhibitor 1) is a protein-coding gene located on chromosome 1.
ERBB receptor feedback inhibitor 1 (ERRFI1) is a protein encoded by the ERRFI1 gene in humans. This protein, also known as MIG6, is a cytoplasmic protein that is upregulated during cell growth. It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling. ERRFI1 has been shown to interact with Stratifin and CDC42.
ERRFI1 acts as a negative regulator of EGFR signaling in skin morphogenesis. It inhibits the activity of several EGFR family members, including ERBB2, ERBB3 and ERBB4, by interfering with their dimerization and inhibiting their autophosphorylation. This protein plays a crucial role in the normal proliferation and differentiation of keratinocytes. Furthermore, it is involved in modulating the response to steroid hormones in the uterus, specifically by regulating the response to progesterone and mediating epithelial estrogen responses. ERRFI1 is essential for normal prenatal and perinatal lung development.
ERRFI1 is also known as GENE-33, MIG-6, MIG6, RALT.
