ERGIC2
Description
The ERGIC2 (ERGIC and golgi 2) is a protein-coding gene located on chromosome 12.
ERGIC2 is a gene located on chromosome 12p11, encoding a protein of 377 amino acids. Its exact function is unknown, but it was initially identified as a potential tumor suppressor for prostate cancer. ERGIC2 is thought to be a chaperone molecule involved in protein trafficking between the endoplasmic reticulum and the Golgi. It contains two hydrophobic transmembrane domains that anchor it to the ER membrane, with its luminal domain facing the ER lumen and its N- and C-termini facing the cytosol. ERGIC2 forms a complex with ERGIC3 and ERGIC32, acting as a shuttle for protein transport between the ER and Golgi. ERGIC2 interacts with various proteins, including beta-amyloid, protein elongation factor 1alpha, and otoferlin, suggesting potential roles beyond protein trafficking. A variant transcript of ERGIC2 has also been reported.
ERGIC2 is also known as CDA14, Erv41, PTX1, cd002.
