ERBB2IP
ERBB2IP: A Gene with Far-Reaching Implications
Description
ERBB2IP, also known as HER2 interacting protein, is a gene that plays a crucial role in cellular signaling pathways. It encodes a protein that interacts with the HER2 receptor, a key regulator of cell growth and proliferation.
ERBB2IP acts as a scaffold protein, bringing together multiple signaling molecules to amplify cellular responses. It enhances HER2 signaling, promoting cell growth and survival. However, dysregulation of ERBB2IP can lead to abnormal cell behavior and contribute to various diseases.
Associated Diseases
Mutations in the ERBB2IP gene have been linked to several types of cancer, including:
- Breast cancer: Amplification of the ERBB2IP gene is a prominent feature in approximately 10-20% of breast cancers.
- Ovarian cancer: High expression of ERBB2IP has been associated with poor prognosis in ovarian cancer patients.
- Lung cancer: ERBB2IP overexpression has been observed in certain subtypes of lung cancer, contributing to cancer cell proliferation and resistance to therapy.
Did you Know ?
According to research published in Nature Communications, overexpression of ERBB2IP in breast cancer cells leads to a 50% increase in cell growth compared to cells with normal ERBB2IP levels. This highlights the significant role of ERBB2IP in regulating cell proliferation.
