EPHX3
Description
The EPHX3 (epoxide hydrolase 3) is a protein-coding gene located on chromosome 19.
Epoxide hydrolase 3 (ABHD9, EH3, EPHX3) is a protein encoded by the EPHX3 gene in humans. It is one of four known epoxide hydrolase isozymes, along with microsomal epoxide hydrolase (EH1), soluble epoxide hydrolase (EH2), and epoxide hydrolase 4 (EH4). All four enzymes share an Alpha/beta hydrolase fold, suggesting they have hydrolytic activity. EH1, EH2, and EH3 have been shown to add water to epoxides of unsaturated fatty acids to produce vicinal cis products; the activity of EH4 is not yet reported. These enzymes differ in subcellular location, tissue expression patterns, substrate preferences, and functions. These functions include regulating the biological actions of certain fatty acid epoxides, increasing the toxicity of other fatty acid epoxides, and participating in the metabolism of drugs and other xenobiotics. EH3 was initially named ABHD9 due to its possession of the Alpha/beta hydrolase fold domain, a common feature in over 30 human hydrolytic enzymes including the four epoxide hydrolases. The gene for EH3 (EPHX3) was identified on chromosome locus 19p13.13 during human genome sequencing. Based on its amino acid sequence, it was predicted to encode a protein with an α/β hydrolase fold domain, leading to its designation as ABHD9.
EH3 catalyzes the hydrolysis of epoxide-containing fatty acids, including epoxyeicosatrienoic acids (EETs) such as 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET, as well as leukotoxin.
EPHX3 is also known as ABHD9, EH3.
