EPHA1
Description
The EPHA1 (EPH receptor A1) is a protein-coding gene located on chromosome 7.
EPHA1, also known as Ephrin type-A receptor 1, is a protein encoded by the EPHA1 gene in humans. It belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors are involved in developmental processes, particularly in the nervous system. EPHA1 has a single kinase domain and an extracellular region with a Cys-rich domain and two fibronectin type III repeats. The ephrin receptors are divided into two groups based on their extracellular domain sequences and their affinities for ephrin-A and ephrin-B ligands. EPHA1 is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
EPHA1 is a receptor tyrosine kinase that binds to ephrin-A family ligands on neighboring cells, initiating contact-dependent bidirectional signaling. It interacts with EFNA1 with high affinity, EFNA3 and EFNA4 with lower affinity, and triggers cell attachment to the extracellular matrix, inhibiting cell spreading and motility. EPHA1 also regulates cell proliferation, angiogenesis, and may be involved in apoptosis.
EPHA1 is also known as EPH, EPHT, EPHT1.
Associated Diseases
- medullary thyroid gland carcinoma
- thyroid cancer
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- lung cancer
