EPCAM
The EPCAM gene encodes a protein known as Epithelial Cell Adhesion Molecule (EpCAM)
Associated Diseases
Lynch Syndrome
Did you know
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common cause of hereditary colorectal (colon) cancer.
People with Lynch syndrome are more likely to get colorectal cancer and other cancers, and at a younger age (before 50), including
- Uterine (endometrial),
- Stomach,
- Liver,
- Kidney,
- Brain, and
- Certain types of skin cancers.
Lynch syndrome is due to inherited changes (mutations) in genes that affect DNA mismatch repair, a process that fixes mistakes made when DNA is copied. These genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) normally protect you from getting certain cancers, but some mutations in these genes prevent them from working properly.
