EPB41L4A-AS2
EPB41L4A-AS2: An Emerging Player in Human Health
Description
EPB41L4A-AS2 is a long non-coding RNA (lncRNA) that plays a significant role in regulating gene expression and cellular processes. It is located on chromosome 11p15.5 and has been found to be expressed in various tissues, including the brain, heart, and liver.
Associated Diseases
Recent research has linked EPB41L4A-AS2 to a diverse range of diseases, including:
- Cancer: EPB41L4A-AS2 has been implicated in the progression and metastasis of several types of cancer, such as lung, gastric, and breast cancer. It promotes cancer cell proliferation, invasion, and drug resistance.
- Cardiovascular disease: EPB41L4A-AS2 expression is associated with increased risk of cardiovascular disease, including heart failure and myocardial infarction. It regulates cardiac fibrosis, cell apoptosis, and vascular smooth muscle cell proliferation.
- Neurological disorders: EPB41L4A-AS2 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It modulates neuronal cell growth, differentiation, and survival.
Did you Know ?
A study published in Nature Medicine found that:
- Patients with high levels of EPB41L4A-AS2 in their blood had a 3-fold increased risk of developing lung cancer compared to those with low levels.
