ENTPD2
Description
The ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2) is a protein-coding gene located on chromosome 9.
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) is a human gene encoding an enzyme called E-NTPDase 2, a member of the ecto-nucleoside triphosphate diphosphohydrolase family. This enzyme is responsible for breaking down 5'-triphosphates, particularly ATP, on the surface of cells. ENTPD2 is an integral membrane protein, and alternative splicing of its gene leads to multiple transcript variants. Interestingly, research from the University of Warwick has shown that ENTPD2 can stimulate eye growth in tadpoles, leading to the development of extra eyes. In the context of embryonic development, studies have identified ENTPD2 as a gene predominantly expressed in the visceral yolk sac (VYS) of mice. The VYS, along with the parietal yolk sac (PYS), serves as a vital exchange system between the mother and fetus, transferring nutrients and eliminating waste. This gene's expression in the VYS highlights its potential role in embryonic development and nutrient transport.
ENTPD2 is also known as CD39L1, NTPDase-2.
