ENO4
Headline: ENO4: A Crucial Enzyme with Far-Reaching Implications in Health and Disease
Description:
ENO4, short for enolase 4, is an enzyme that plays a pivotal role in numerous biological processes. It is primarily involved in glycolysis, the metabolic pathway responsible for converting glucose into energy. ENO4's specific function is to catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate, a key step in the production of adenosine triphosphate (ATP).
ENO4 is widely expressed throughout the body, but it is particularly abundant in highly metabolically active tissues such as muscle, brain, and red blood cells. It is also found in many cancer cells, where it contributes to their aggressive growth and survival.
Associated Diseases:
ENO4 dysregulation has been implicated in a range of diseases, including:
- Cancer: ENO4 overexpression is associated with increased tumor growth, metastasis, and resistance to therapy in various cancers, such as breast, lung, and colorectal cancer.
- Neurological disorders: Mutations in the ENO4 gene have been linked to Leigh syndrome, a rare mitochondrial disorder that affects the nervous system.
- Metabolic disorders: ENO4 deficiency can lead to pyruvate dehydrogenase deficiency, a condition that impairs the body's ability to use glucose for energy.
Did you Know ?
- ENO4 is the most abundant protein in human red blood cells, accounting for approximately 6% of their total protein content.
