ENDOU

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Description

The ENDOU (endonuclease, poly(U) specific) is a protein-coding gene located on chromosome 12.

ENDOU is an endoribonuclease that breaks down single-stranded RNA molecules. It specifically targets uridylates (U) within the RNA sequence, cutting the strand at the 5' end of the U. This cleavage results in a product with a 2',3'-cyclic phosphate at its 3' end. ENDOU prefers to cleave at UU and GU sites, showing greater efficiency compared to CU and AU sites.

ENDOU is also known as P11, PP11, PRSS26.

Associated Diseases

• brain injury
• retinitis pigmentosa
• X-linked retinal dysplasia
• severe early-childhood-onset retinal dystrophy
• reticular dystrophy of the retinal pigment epithelium
• choroidal dystrophy, central areolar, 1
• age related macular degeneration 11
• age related macular degeneration 7
• age related macular degeneration 4
• coloboma of macula
• X-linked retinoschisis
• coloboma of optic nerve