EMC7
Description
The EMC7 (ER membrane protein complex subunit 7) is a protein-coding gene located on chromosome 15.
EMC7 is a component of the endoplasmic reticulum membrane protein complex (EMC) that facilitates the energy-independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. It preferentially interacts with proteins possessing transmembrane domains that exhibit weak hydrophobicity or contain destabilizing features like charged and aromatic residues. EMC7 participates in the cotranslational insertion of multi-pass membrane proteins, where stop-transfer membrane-anchor sequences become ER membrane spanning helices. Additionally, it plays a crucial role in the post-translational insertion of tail-anchored (TA) proteins into the ER membrane. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with the translocated N-terminus residing within the ER lumen, EMC7 regulates the topology of multi-pass membrane proteins such as G protein-coupled receptors. Through its regulation of protein insertion into membranes, EMC7 indirectly influences various cellular processes.
EMC7 is also known as C11orf3, C15orf24, HT022, ORF1-FL1.
