EMC3
Description
The EMC3 (ER membrane protein complex subunit 3) is a protein-coding gene located on chromosome 3.
EMC3 is a component of the endoplasmic reticulum membrane protein complex (EMC) that facilitates the energy-independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum. It preferentially accommodates proteins with weakly hydrophobic transmembrane domains or those containing destabilizing features, such as charged or aromatic residues. EMC3 participates in the cotranslational insertion of multi-pass membrane proteins, where stop-transfer membrane-anchor sequences become ER membrane-spanning helices. It is also required for the post-translational insertion of tail-anchored (TA) proteins into the endoplasmic reticulum. By ensuring the correct cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with the translocated N-terminus in the ER lumen, EMC3 controls the topology of multi-pass membrane proteins, such as G protein-coupled receptors. Through its regulation of protein insertion into membranes, EMC3 indirectly influences numerous cellular processes.
EMC3 is also known as POB, TMEM111.
