ELK3
Description
The ELK3 (ETS transcription factor ELK3) is a protein-coding gene located on chromosome 12.
ELK3 is a protein that belongs to the ETS-domain transcription factor family and specifically the ternary complex factor (TCF) subfamily. These proteins are involved in regulating gene expression by binding to serum response elements alongside the serum response factor. ELK3's activity is triggered by signals that lead to its phosphorylation. Studies in rodent models suggest that ELK3 acts as a transcriptional inhibitor without Ras, but promotes transcription when Ras is present. ELK3 has been shown to interact with another transcription factor, TCF3.
ELK3 can act as a negative regulator of transcription, but its activity can be switched to activation when coexpressed with proteins like Ras, Src, or Mos. This switch in activity is likely due to the formation of a ternary complex involving ELK3, the serum response factor (SRF), and specific DNA motifs within the Fos serum response element.
ELK3 is also known as ERP, NET, SAP-2, SAP2.
Associated Diseases
- X-linked retinal dysplasia
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- severe early-childhood-onset retinal dystrophy
- isolated asymptomatic elevation of creatine phosphokinase
- age related macular degeneration 4
- age related macular degeneration 7
- age related macular degeneration 11
- thyroid hormone metabolism, abnormal, 2
