ELK1

Description

The ELK1 (ETS transcription factor ELK1) is a protein-coding gene located on chromosome X.

Elk-1, encoded by the ELK1 gene, is a transcription activator that acts as a ternary complex factor (TCF). It belongs to the ETS family, known for its DNA-binding domain. Elk-1 plays crucial roles in various processes, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression. The Elk-1 protein consists of several domains: the A domain, located in the N-terminal region, is responsible for DNA binding, nuclear import, and export. The B domain binds to the dimer of its cofactor, SRF. The R domain inhibits Elk-1 transcriptional activity and undergoes SUMOylation. The D domain binds to active Mitogen-activated protein kinases (MAPKs).

ELK1 is also known as -.

Associated Diseases

• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failure 3
• hyperinsulinism due to INSR deficiency
• spermatogenic failure 7
• spermatogenic failure 29
• partial chromosome Y deletion
• hyperinsulinism due to glucokinase deficiency
• spermatogenic failure 11
• spermatogenic failure 10
• spermatogenic failure 70
• spermatogenic failure 45
• spermatogenic failure 49
• spermatogenic failure 43
• spermatogenic failure 19
• spermatogenic failure 47
• spermatogenic failure 41
• spermatogenic failure 27
• spermatogenic failure 46
• spermatogenic failure 18