EIF4G2
Description
The EIF4G2 (eukaryotic translation initiation factor 4 gamma 2) is a protein-coding gene located on chromosome 11.
EIF4G2 is a protein involved in translation initiation. It is similar to another protein called EIF4G1, but it functions as a general repressor of translation, forming inactive complexes. Unlike EIF4G1, which can use both the cap structure and other mechanisms to start translation, EIF4G2 only uses the cap structure. There are different forms of EIF4G2, created by alternative splicing of its gene.
EIF4G2 is involved in the transition from cap-dependent to IRES-mediated translation during cell division (mitosis), programmed cell death (apoptosis), and viral infection. It can be broken down (cleaved) by certain enzymes called caspases and viral proteases.
EIF4G2 is also known as AAG1, DAP5, NAT1, P97.
Associated Diseases
- coronary artery disease, autosomal dominant 2
- cancer
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
- microphthalmia with limb anomalies
- hyperinsulinism due to INSR deficiency
- hyperinsulinism due to HNF1A deficiency
