EIF4G1
Description
The EIF4G1 (eukaryotic translation initiation factor 4 gamma 1) is a protein-coding gene located on chromosome 3.
Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.
== Function == The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.
== Interactions == Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1, EIF4A1, EIF4E, MKNK2 and PABPC1.
EIF4G1, also known as eIF-4-gamma 1, eIF-4G 1, or eIF-4G1, is a component of the eIF4F complex, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. EIF4G1 exists in two mutually exclusive complexes: one with EIF1 and the other with EIF4E. In the EIF1-EIF4G1 complex, EIF4G1 is required for leaky scanning, which allows ribosomes to bypass the first start codon and initiate translation at a downstream site. In the EIF4E-EIF4G1 complex, EIF4G1 antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon through a TISU element without scanning. As a member of the eIF4F complex, EIF4G1 is required for endoplasmic reticulum stress-induced ATF4 mRNA translation.
EIF4G1 is also known as EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18.
