EIF4ENIF1
Description
The EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1) is a protein-coding gene located on chromosome 22.
Eukaryotic translation initiation factor 4E transporter (4E-T, eIF4E transporter), also known as Eukaryotic translation initiation factor 4E nuclear import factor 1, is a protein that in humans is encoded by the EIF4ENIF1 gene. The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.
EIF4ENIF1, also known as 4E-T or eIF4E transporter, is a key protein in the regulation of mRNA translation and stability within processing bodies (P-bodies). It plays a crucial role in P-body formation, coordinating the storage and preventing degradation of translationally inactive mRNAs in the cytoplasm. EIF4ENIF1 acts as a central hub for several RNA-binding proteins, impacting mRNA fate. It promotes deadenylation via interaction with the CCR4-NOT complex and inhibits decapping via interaction with eIF4E (including EIF4E and EIF4E2), safeguarding deadenylated and repressed mRNAs from degradation. EIF4ENIF1 contributes to the repression of proneurogenic factors during neurogenesis, facilitates miRNA-mediated translational repression, and is required for the formation of P-bodies. Additionally, it participates in mRNA translational repression mediated by the miRNA effector TNRC6B, protecting TNRC6B-targeted mRNAs from decapping and subsequent decay. Besides its role in P-bodies, EIF4ENIF1 functions as a nucleoplasmic shuttling protein. It mediates the nuclear import of EIF4E and DDX6 through a piggy-back mechanism. Its interactions with various proteins, including EIF4E, EIF4E2, DDX6, CSDE1/UNR, CNOT1, LSM14A, PATL1, and importin alpha, highlight its intricate role in cellular processes.
EIF4ENIF1 is also known as 4E-T, Clast4.
Associated Diseases
- lysosomal storage disease
- type 2 diabetes mellitus
- acral self-healing collodion baby
- Kaposi sarcoma, susceptibility to
