EIF4EBP2
Description
The EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2) is a protein-coding gene located on chromosome 10.
EIF4EBP2, encoded by the EIF4EBP2 gene, is a protein involved in translation initiation. Knockout mice lacking the Eif4ebp2 gene exhibit autism-like symptoms, including impaired social interaction, altered communication, and repetitive behaviors. These mice have elevated levels of Neuroligins, suggesting a potential link between EIF4EBP2 and autism.
EIF4EBP2 acts as a repressor of translation initiation, playing a crucial role in synaptic plasticity, learning, and memory formation. It regulates the activity of EIF4E by preventing its assembly into the eIF4F complex. The hypophosphorylated form of EIF4EBP2 strongly binds to EIF4E, competing with EIF4G1/EIF4G3 and inhibiting translation. Conversely, the hyperphosphorylated form dissociates from EIF4E, allowing EIF4G1/EIF4G3 to bind and initiating translation. EIF4EBP2 is highly concentrated in the brain, functioning as a regulator of synapse activity and neuronal stem cell renewal through its ability to suppress translation initiation. It mediates the regulation of protein translation by hormones, growth factors, and other stimuli that signal through the MAP kinase and mTORC1 pathways.
EIF4EBP2 is also known as 4EBP2, PHASII.
Associated Diseases
- cancer
- fragile X syndrome
- malignant glioma
- autism spectrum disorder - epilepsy - arthrogryposis syndrome
- major depressive disorder
