EIF3CL
Description
The EIF3CL (eukaryotic translation initiation factor 3 subunit C like) is a protein-coding gene located on chromosome 16.
EIF3CL is a protein in humans encoded by the EIF3CL gene. It's a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to initiate translation. Multiple transcript variants encoding the same protein have been identified for this gene.
EIF3CL is a subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex, which plays a crucial role in the initiation of protein synthesis. The eIF-3 complex interacts with the 40S ribosome, facilitating the assembly of the 43S pre-initiation complex (43S PIC) by recruiting key factors like eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5. This complex further promotes mRNA recruitment to the 43S PIC and facilitates scanning for the AUG start codon. Additionally, the eIF-3 complex participates in the disassembly and recycling of ribosomes after protein synthesis, preventing premature joining of the ribosomal subunits. Notably, eIF-3 exhibits specificity in targeting and initiating translation of mRNAs associated with cell proliferation, including cell cycle regulation, differentiation, and apoptosis. It utilizes distinct RNA stem-loop binding mechanisms to regulate translation, either activating or repressing protein production.
EIF3CL is also known as -.
Associated Diseases
- common variable immunodeficiency
- type 1 diabetes mellitus
- systemic lupus erythematosus
- syndactyly type 4
- Griscelli syndrome type 3
- osteopathia striata-pigmentary dermopathy-white forelock syndrome
- polydactyly of a triphalangeal thumb
