EIF2S2
Description
The EIF2S2 (eukaryotic translation initiation factor 2 subunit beta) is a protein-coding gene located on chromosome 20.
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein encoded by the EIF2S2 gene. It is a component of the eukaryotic translation initiation factor 2 (eIF2) complex, which is involved in the early steps of protein synthesis. eIF2 forms a ternary complex with GTP and initiator tRNA, and binds to a 40S ribosomal subunit. eIF2 is composed of three subunits: alpha (α), beta (β), and gamma (γ), with EIF2S2 encoding the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation. The expression of both eIF2α and eIF2β is regulated by the NRF1 transcription factor.
EIF2S2, also known as Eukaryotic translation initiation factor 2 subunit beta, is a component of the eIF2 complex. The eIF2 complex functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex. The junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. For eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP through a reaction catalyzed by eIF2B.
EIF2S2 is also known as EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta.
