EIF2D
Description
The EIF2D (eukaryotic translation initiation factor 2D) is a protein-coding gene located on chromosome 1.
Ligatin, also known as eIF2D, is a protein encoded by the LGTN gene in humans. Unlike the heterotrimeric eIF2 complex, it functions in different pathways of eukaryotic translation. Ligatin acts as a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. Ligatin contains single PUA and SUI1 domains which may function in RNA binding and translation initiation, respectively.
EIF2D is also known as HCA56, LGTN.
Associated Diseases
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome
- immunodeficiency 75
- glycoprotein storage disease
- neuronal ceroid lipofuscinosis 1
- hemoglobin H disease
- hemoglobin C-beta-thalassemia syndrome
- dominant beta-thalassemia
- combined immunodeficiency due to OX40 deficiency
- hereditary neutrophilia
- familial isolated congenital asplenia
- erythroleukemia, familial, susceptibility to
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- trimethylaminuria
