EIF2A
Description
The EIF2A (eukaryotic translation initiation factor 2A) is a protein-coding gene located on chromosome 3.
The eukaryotic translation initiation factor 2A (eIF2A) is a protein encoded by the EIF2A gene in humans. It is distinct from eIF2α, a subunit of the eIF2 complex. eIF2A functions independently in eukaryotic translation and is a 65 kDa protein that facilitates the formation of puromycin-sensitive 80S preinitiation complexes. While it may contribute to translation initiation mediated by the HCV IRES under stress conditions, this finding is debated.
eIF2A plays a role in the initial stages of protein synthesis for a limited set of specific messenger RNA molecules (mRNAs). It facilitates the attachment of methionyl-tRNAi (a special type of transfer RNA carrying the amino acid methionine) to the 40S ribosomal subunit. Unlike the eIF-2 complex, eIF2A binds methionyl-tRNAi to the 40S subunit in a manner dependent on the genetic code (codon), while the eIF-2 complex relies on the presence of GTP (a molecule essential for energy).
EIF2A is also known as CDA02, EIF-2A, MST089, MSTP004, MSTP089.
Associated Diseases
- congenital hypothyroidism
- beta-thalassemia-X-linked thrombocytopenia syndrome
- dominant beta-thalassemia
- hemoglobin D disease
- hemoglobin H disease
- erythroleukemia, familial, susceptibility to
- hemoglobin C-beta-thalassemia syndrome
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome
- hemoglobin E disease
- bleeding disorder, platelet-type, 24
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- dehydrated hereditary stomatocytosis
- platelet-type bleeding disorder 15
- thrombocytopenia, anemia, and myelofibrosis
