EIF1
Eukaryotic Initiation Factor 1 (eIF1): A Key Player in Protein Translation
Description:
Eukaryotic initiation factor 1 (eIF1) is a critical protein complex that plays a crucial role in the initiation of protein translation in eukaryotic cells. It consists of three subunits: eIF1A, eIF1B, and eIF1C.
eIF1 is responsible for binding to the small ribosomal subunit (40S) and initiating the recruitment of the messenger RNA (mRNA) and the tRNA carrying the initiating methionine amino acid. This step marks the beginning of protein synthesis.
Associated Diseases:
Mutations or dysregulation of eIF1 have been linked to several diseases, including:
- Cancer: eIF1 overexpression has been observed in various types of cancer, such as breast cancer, lung cancer, and hepatocellular carcinoma.
- Neurological disorders: Mutations in eIF1 genes have been associated with neurodevelopmental disorders such as Rett syndrome and X-linked intellectual disability.
- Autoimmune diseases: eIF1 dysregulation has been implicated in autoimmune diseases like systemic lupus erythematosus and rheumatoid arthritis.
Did you Know ?
In a study of breast cancer patients, researchers found that eIF1 overexpression was associated with a significantly shorter overall survival rate. This suggests that eIF1 plays a critical role in cancer progression and prognosis.
