EID1
Description
The EID1 (EP300 interacting inhibitor of differentiation 1) is a protein-coding gene located on chromosome 15.
EP300-interacting inhibitor of differentiation 1 is a protein encoded by the EID1 gene in humans. EID1 interacts with EP300 and the Retinoblastoma protein.
EID1 interacts with RB1 and EP300, acting as a repressor of MYOD1 transactivation. It inhibits EP300 and CBP histone acetyltransferase activity. EID1 may play a role in linking cell cycle exit to the transcriptional activation of genes necessary for cellular differentiation. It might also act as a coinhibitory factor for NR0B2, potentially directly involved in transcription inhibition.
EID1 is also known as C15orf3, CRI1, EID-1, IRO45620, PNAS-22, PTD014, RBP21.
Associated Diseases
- type 1 diabetes mellitus
- schizophrenia
- oculocerebrorenal syndrome
- Ehlers-Danlos syndrome
- bipolar disorder
- cancer
- Emery-Dreifuss muscular dystrophy
