EGFR

Description

The EGFR gene, also known as the epidermal growth factor receptor gene, provides instructions for creating a protein that plays a vital role in cell growth, division, and survival. This protein, known as the epidermal growth factor receptor (EGFR), sits on the surface of cells and acts as a receptor for certain growth factors. When these factors bind to EGFR, it triggers a cascade of signals within the cell, ultimately promoting cell growth and division. This complex process is tightly regulated to ensure healthy cell development. However, mutations in the EGFR gene can lead to uncontrolled cell growth and division, contributing to the development of various cancers.

Associated Diseases

• Lung cancer (Non-small cell lung cancer, NSCLC)
• Colorectal cancer
• Breast cancer
• Glioblastoma
• Head and neck cancer

Did you know?

Mutations in the EGFR gene are particularly common in lung cancer patients who have never smoked.