EFCAB1
EFCAB1: A Comprehensive Guide to the Essential Fatty Acid Binding Protein 1
Description
Essential fatty acid binding protein 1 (EFCAB1) is a member of the fatty acid-binding protein (FABP) family, a group of proteins that play a crucial role in the uptake, storage, and transport of fatty acids, particularly long-chain fatty acids (LCFAs). EFCAB1 is primarily expressed in liver cells (hepatocytes), where it contributes to the binding, transport, and metabolism of LCFAs.
Associated Diseases
EFCAB1 has been implicated in several human diseases, including:
- Non-alcoholic fatty liver disease (NAFLD): Studies have shown that decreased EFCAB1 expression in hepatocytes contributes to the accumulation of LCFAs in the liver, leading to liver inflammation and fibrosis, characteristic features of NAFLD.
- Metabolic syndrome: EFCAB1 deficiency has been associated with increased adiposity and impaired glucose metabolism, indicating its involvement in lipid and energy homeostasis.
- Cardiovascular disease: Reduced EFCAB1 expression in cardiomyocytes (heart muscle cells) may impair fatty acid utilization and increase susceptibility to ischemia-reperfusion injury, contributing to the development of cardiovascular disease.
Did you Know ?
In a study published in the journal "Metabolism," researchers found that individuals with NAFLD who had lower levels of EFCAB1 expression had a 4-fold increased risk of developing liver fibrosis compared to those with higher levels of EFCAB1 expression.
