EED
Description
The EED (embryonic ectoderm development) is a protein-coding gene located on chromosome 11.
EED refers to the human gene encoding the Embryonic ectoderm development protein, also known as WD protein associating with integrin cytoplasmic tails 1.
EED is a component of the Polycomb Repressive Complex 2 (PRC2), which plays a crucial role in gene silencing. PRC2 is responsible for methylating histone H3 at lysine 9 and lysine 27, leading to transcriptional repression of the target genes. EED's interaction with trimethylated histone H1 at lysine 26 inhibits PRC2's methyltransferase activity on histone H3 lysine 27, while its recognition of H3 lysine 27 promotes the propagation of this repressive mark. PRC2, through EED, can recruit DNA methyltransferases, establishing a connection between epigenetic repression systems. Some of the genes repressed by PRC2 include HOXC8, HOXA9, MYT1, and CDKN2A.
EED is also known as COGIS, HEED, WAIT1.
