EDF1
Description
The EDF1 (endothelial differentiation related factor 1) is a protein-coding gene located on chromosome 9.
EDF1, encoded by the EDF1 gene, is a protein believed to regulate endothelial cell differentiation. It may act as a bridge connecting regulatory proteins and the basal transcription machinery, influencing the transcription of genes involved in endothelial differentiation. EDF1 can also serve as a transcriptional coactivator by linking the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two distinct protein variants of EDF1 exist, produced from alternatively spliced transcripts of the EDF1 gene. EDF1 has been shown to interact with Liver X receptor alpha, Peroxisome proliferator-activated receptor gamma, and TATA binding protein.
EDF1 acts as a transcriptional coactivator, boosting the activity of NR5A1, NR1H3/LXRA, and PPARG. It enhances the DNA-binding capabilities of ATF1, ATF2, CREB1, and NR5A1. EDF1 likely regulates nitric oxide synthase activity by retaining calmodulin in the cytoplasm. It is implicated in processes like endothelial cell differentiation, hormone-induced cardiomyocyte hypertrophy, and lipid metabolism.
EDF1 is also known as CFAP280, EDF-1, MBF1.
