EDEM2
Description
The EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2) is a protein-coding gene located on chromosome 20.
EDEM2, or ER degradation-enhancing alpha-mannosidase-like 2, is an enzyme produced by the EDEM2 gene in humans.
EDEM2 plays a critical role in the endoplasmic reticulum-associated degradation (ERAD) pathway, which targets misfolded glycoproteins for destruction. This process is dependent on N-glycans. EDEM2 may initiate ERAD by catalyzing the initial mannose trimming step, converting Man9GlcNAc2 to Man8GlcNAc2. Additionally, EDEM2 appears to recognize and bind to exposed hydrophobic regions within target proteins. These findings are supported by multiple sources, including UniProtKB (Q8BJT9) and PubMed articles (15537790, 25092655).
EDEM2 is also known as C20orf31, C20orf49, bA4204.1.
