E4F1
E4F1: A Complex Gene with Far-Reaching Implications
Description:
E4F1 (E2F transcription factor 1) is a gene that plays a crucial role in cell cycle regulation, growth, and differentiation. It is a member of the E2F family of transcription factors, which regulate gene expression by binding to specific DNA sequences and controlling the initiation of DNA replication.
E4F1 is particularly involved in the transition from the G1 to S phase of the cell cycle, known as the DNA synthesis phase. It promotes cell cycle progression by activating the expression of genes involved in DNA replication and cell division.
Associated Diseases:
Dysregulation of E4F1 has been linked to several diseases, including:
- Cancer: Aberrant E4F1 expression can promote cell proliferation and inhibit apoptosis (cell death), contributing to the development and progression of various cancers, including breast, lung, and prostate cancer.
- Neurological disorders: Mutations in E4F1 have been associated with intellectual disability, autism spectrum disorder, and Rett syndrome.
- Skin conditions: E4F1 is involved in the regulation of keratinocyte differentiation, and its dysfunction can lead to skin diseases such as psoriasis and atopic dermatitis.
Did you Know ?
- E4F1 is overexpressed in approximately 50% of breast cancer cases, indicating its potential role in cancer development.
