E2F1
Description
The E2F1 gene plays a crucial role in regulating cell cycle progression and cellular growth. It encodes a transcription factor that controls the expression of genes involved in DNA replication, cell division, and apoptosis. E2F1 activity is tightly regulated by various factors, including cell cycle checkpoints, growth factors, and tumor suppressor proteins. Dysregulation of E2F1 expression or function can lead to uncontrolled cell proliferation and cancer development.
Associated Diseases
- Cancer (various types, including breast, lung, and colon cancer)
- Neurological disorders (e.g., Alzheimer‘s disease)
- Cardiovascular disease
- Immune disorders
Did you know?
E2F1 was initially identified as a binding factor for the adenovirus E2 promoter, highlighting its involvement in viral replication.
