DZIP1
Description
The DZIP1 (DAZ interacting zinc finger protein 1) is a protein-coding gene located on chromosome 13.
DZIP1 (Zinc finger protein DZIP1) is a protein encoded by the DZIP1 gene in humans.
DZIP1, also known as DAZ-interacting protein 1/2 or DAZ-interacting zinc finger protein 1, acts as a molecular adapter crucial for assembling and maintaining cilia. During the cell cycle, DZIP1 localizes to the basal body of forming primary cilia, where it recruits and activates RAB8A, a protein involved in transporting proteins for cilium formation. It also recruits the BBSome, a complex important for cilia biogenesis, by linking it to PCM1 at centriolar satellites. DZIP1 is required for the recruitment of intraflagellar transport (IFT) machinery and ciliary appendage proteins like CEP164 and NINEIN to the cilium basal body. This protein regulates Hedgehog signaling through its role in cilium assembly and potentially by retaining GLI3 in the cytoplasm. DZIP1 is also crucial for spermatogenesis, participating in basal body organization and sperm flagellum assembly. It indirectly influences heart development through its role in ciliogenesis. DZIP1 interacts with various proteins including DAZ1, BBSome, PCM1, RAB8A, GDI2, GLI3, CEP164, and IFT88, each playing a role in different aspects of cilium assembly, transport, and signaling.
DZIP1 is also known as DZIP, DZIPt1, MMVP3, MVP3, SPGF47.
