DYNLT1
Description
The DYNLT1 (dynein light chain Tctex-type 1) is a protein-coding gene located on chromosome 6.
Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides.
DYNLT1 acts as a non-catalytic accessory component of the cytoplasmic dynein 1 complex. It helps link dynein to cargos and adapter proteins, regulating dynein function. Cytoplasmic dynein 1 is responsible for the retrograde movement of vesicles and organelles along microtubules. DYNLT1 facilitates the binding of cargos to dynein, including apical cargo transport like rhodopsin-bearing vesicles in polarized cells. It might also be involved in the function of axonemal dynein.
DYNLT1 is also known as CW-1, TCTEL1, TCTEX1, tctex-1.
