DYNLRB1
Description
The DYNLRB1 (dynein light chain roadblock-type 1) is a protein-coding gene located on chromosome 20.
DYNLRB1 is a gene that encodes a protein called Dynein light chain roadblock-type 1. This protein belongs to the roadblock dynein light chain family and is found in the cytoplasm. It can bind to intermediate chain proteins. Increased levels of DYNLRB1 have been linked to hepatocellular carcinomas, suggesting a potential role in tumor development.
DYNLRB1 is a non-catalytic accessory component of the cytoplasmic dynein 1 complex. It helps connect dynein to cargo and adapter proteins, playing a role in regulating dynein's function. Cytoplasmic dynein 1 functions as a motor protein, facilitating the retrograde movement of vesicles and organelles along microtubules within cells.
DYNLRB1 is also known as BITH, BLP, DNCL2A, DNLC2A, ROBLD1.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- multiple sclerosis
- cancer
- Gorham-Stout disease
- melorheostosis
