DUSP5

---

Description

The DUSP5 (dual specificity phosphatase 5) is a protein-coding gene located on chromosome 10.

Dual specificity protein phosphatase 5 (DUSP5) is an enzyme produced by the DUSP5 gene in humans. It belongs to the dual specificity protein phosphatase subfamily, which inactivates kinases by removing phosphate groups from phosphoserine/threonine and phosphotyrosine residues. DUSP5 specifically regulates members of the mitogen-activated protein (MAP) kinase superfamily, including MAPK/ERK, SAPK/JNK, and p38, which are involved in cellular growth and differentiation. DUSP5 inactivates ERK1/2 and is found in various tissues, with the highest concentrations in the pancreas and brain. It is localized within the nucleus.

DUSP5 is also known as DUSP, HVH3.

Associated Diseases

• thyroid gland adenocarcinoma
• endometrial cancer
• immunodeficiency 18
• reticular dysgenesis
• common variable immunodeficiency
• severe combined immunodeficiency due to CARD11 deficiency
• severe combined immunodeficiency due to CTPS1 deficiency
• Wiskott-Aldrich syndrome
• hyper-IgM syndrome type 3
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• isolated agammaglobulinemia
• combined immunodeficiency with skin granulomas
• immunodeficiency, common variable, 4