DUSP4
Description
The DUSP4 (dual specificity phosphatase 4) is a protein-coding gene located on chromosome 8.
Dual specificity protein phosphatase 4 is an enzyme encoded by the DUSP4 gene in humans. It belongs to the dual specificity protein phosphatase subfamily, which inactivates target kinases by removing phosphate groups from both phosphoserine/threonine and phosphotyrosine residues. These phosphatases negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are involved in cellular proliferation and differentiation. DUSP4 specifically inactivates ERK1, ERK2, and JNK. It is expressed in various tissues and is found in the nucleus. Two alternative splicing variants, resulting in distinct isoforms, have been observed for this gene. Additionally, multiple polyadenylation sites have been reported.
DUSP4 is also known as HVH2, MKP-2, MKP2, TYP.
